In the opening sequence, when Wayne runs from the meteor about to hit the ground, he isn't wearing his fireman's jacket. When he is shown with his back to the camera looking at the explosion, he is wearing a jacket.
When the meteor hits Wayne's car, the windscreen can be clearly seen flying off into the air and smashing, but later when the police turn the car over the windscreen is back on the car with very little damage.
Towards the end of the movie, when the party at the College is first shown, the Jeep is clearly parked and no one is in it. In the next scene, the characters are shown rolling up and parking at the college.
The time on the digital clock behind the Governor jumps around between shots.
When Wayne's car is hit by the meteor the front wheel is hanging from the axle, but when the car is being flipped by the cops the wheel is fine and he drives off.
The Kuwaiti Liberation Medal ribbon on General Woodman's uniform is upside down in at least one scene where he is using binoculars.
(at around 26 mins) Generals wear stars centered on the epaulets and not by the shoulder seam.
Generals and CDC scientists do not argue cases in court or ask questions of witnesses.
A fair bit of the "science" is bogus. The film is a comedy, not a documentary.
At the end of the movie, when the three heroes are in the Head and Shoulders commercial, they pull each pull out a bottle. Harry is clearly holding the bottle with the back label facing forward, rather than the front of the bottle. This is an intentional gag.
When Wayne throws the match into the shack to start the fire, the match can be seen bouncing off the window frame, yet the fire still starts.
As the shampoo is being pumped into the alien to kill it, the fire hose delivering it is still flat and empty.
When the three hunters shoot the flying monster in the mall, they walk over to it and it begins to move. All three lower and fire their pump shotguns once, indicating that each now has a spent shell in the chamber. Moments later, when they do the tough-guy move racking the slides in unison, no shell is ejected from any of the shotguns.
When the match hits the liquid making the alien grow, one of the legs pushes the coffee cup off the ledge, and coffee cups breaking can be heard breaking on the floor. If watched closely, the coffee cup breaks as it falls off the ledge.
When the scientists go into the nest-cave to fill it with Head and Shoulders, Ira tells Wayne to go out and wait for his signal. Ira and the rest then go into the cave, dragging the fire hose, but as Wayne gets out the fire hose remains still.
The forest camouflage fatigues worn by the soldiers are of a 1980s design, which had been retired well before 2001. The uniform the Soldiers are wearing is the Battle Dress Uniform (BDU), also called "Woodland Pattern" not "Forest," which was standard issue until 2006. The ACU pattern was introduced in 2004 but was not standard issue or a required uniform until April 2008 for active duty and even later dates for the Reserve components.
Nadine hopes to enter a school which will make her eligible to become Miss Arizona. At the end, she apparently is Miss Arizona, but the movie time frame is too short to allow for this accomplishment.
60% of the population of Page AZ is Native American, mostly Navajo. There is not a single Native American shown in the movie.
Ira's Colonel's shoulder boards are on the wrong sides. The eagle's head should be facing forward, not to the rear.
The characters refer to the USGS as the United States Geological Society repeatedly. The real USGS is the United States Geological Survey, referred to as such less frequently in the movie's dialog.
Ira claims that when The Army raided the lab they took everything including the Hard drives from their computers. If the drives had been removed the computer Ira is shown searching right after raid wouldn't have even booted up let alone be searched.
After Ira reads the C- paper, he says "The end" with a short "e" vowel. Whenever a vowel comes after the word "the", the "e" vowel should be long, not short.