It's the 22nd Century, and crime has been almost eradicated in "New London", thanks to a rehabilitation program known as "cripnotism." However, a new crime wave makes it appear that cripnotism is no longer working. Inspector LaStrade (great-great-however many greats -granddaughter of the Inspector LaStrade that worked with Sherlock Holmes over two hundred years ago) has a run in with the mastermind, who looks just like Professor Moriarity. Then she hears a news release about a scientific breakthrough that makes reanimating dead tissue possible. Mistakenly believing that the man she saw is a 'reanimated' Moriarity, she insists on trying the process on Sherlock Holmes. It works, and they, acommpanied by a robo-droid that she has nicknamed Watson, begin unraveling the mystery. Later on, Watson adopts a mask of the original Dr. John Watson, to make Holmes feel more comfortable with it. The series actually does a good job of capturing Arthur Conan Doyle's original character, although he does use Basil Rathbone's line, "Elementary, My dear Watson" quite a bit.