- On some streaming services, the score plays on the soundtrack as opposed to a pop song during the opening scene.
- On the VHS version of the film, "Electric Avenue" by Eddy Grant plays instead of the remix of "Hot Blooded" by Foreigner during the opening chase scene.
- In some prints of the film, the opening scene in the zoo is scored to De La Soul's "Turn it Out".
- Gonad's Gym logo appears on Drix's suitcase during a scene in police station locker room. In an earlier "cut" of the film, Ozzy and Drix visit an amusement park behind Frank's eye, called "See World".
- The DVD release contains three extended (and half-animated) scenes, all of which appear in cut-down form in the final edit:
- Drix and Jones visit the eyes, while Drix complains that he has to visit the nose and the throat. Jones gets donuts and calls the infodesk on his cell phone while at the eyes.
- Frank picks his nose during the dam-bursting sequence, and Jones saves Drix from ending up on Frank's fingertip. In the end, they're snorted back up into the sinuses.
- The race to catch Thrax on his way to the uvula is extended; we see Thrax leap from his car and glide away. Then, after Jones takes the wrong turn, he takes a "shortcut" to the uvula by way of the esophogus, riding a massive acidic Frank-belch up the throat.
- An easter egg on the DVD release shows an energetic montage of action sequences and other shots from the movie.
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