Patrick Warburton improvised when Kronk hummed his own theme song when he was carrying Kuzco (David Spade) in the bag to the waterfall. Disney's legal department had Warburton sign all rights to the humming composition over to them.
Pacha's (John Goodman) wife, Chicha (Wendie Malick) is pregnant. According to the DVD commentary, this is the first Disney animated feature to show a pregnant woman. And one of the first human mothers not to be villainized or killed.
Kuzco was named after the ancient capital of the Incas, Cuzco. The city still exists in the Andes mountains in southern Peru, at an elevation of 11,200 feet (3,200 meters).
Kuzco's 'funeral portrait' is a weave because the Incans were known for their textile arts rather than paintings
Two subtle visual jokes: when Yzma (Eartha Kitt) pours the "drink" into the cactus plant, after Kuzco (David Spade) neck transforms, the cactus turns into the shape of a llama. When Kronk (Patrick Warburton) is trying to hide in the background with Kuzco in the bag, the scene pulls back to reveal a painting of two figures pointing at Kronk.