The first 12 episodes were based on the 12 Steps of Alcoholics Anonymous. Larroquette is a recovering alcoholic in real life.
The series' original working title was "Crossroads," but NBC insisted on "The John Larroquette Show." Larroquette did not want his name in the title.
Larroquette owns the sign in John Hemingway's office that read "This Is A Dark Ride."
The show's tone was lightened after the first season.
David Cassidy wrote the theme song for this show.