The film cost $1.5 million making it Henenlotter's most expensive (at the time), but there were still budgetary issues. The producers told him they had used up all of the allotted funds for pyrotechnics during the exploding hookers scene to which he replied "How the fuck am I gonna film the lab scene?!" He ended up calling in a favor to do some "unlicensed pyrotechnics" for the shoot. Lorinz recalls the guy finishing the setup and telling him "Don't worry, it's maybe safe."
Writer/director Frank Henenlotter improvised the basic story at a pitch meeting. After getting the okay to make the picture, he then wrote the script for the movie.
The interior of the Franken family garage is intentionally four times as large as the exterior, as specified in the screenplay.
Bill Murray is a big fan of this movie, and publicly endorsed it around the time of its release.
Elizabeth has the last name of Shelley. This is an homage to Mary Shelley, the author of the original "Frankenstein".
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