- In the UK, the "U.S. Acres" segments on the show have been re-titled "Orson's Farm" (although the segments are still listed as "U.S. Acres" in the end credits).
- In cable and syndicated reruns the show is subjected to some changes:
- The original theme used during the first two seasons is replaced by the more familiar Latin-styled theme (originally used from 1990 to 1994).
- The "quickies" are rearranged or sometimes eliminated entirely.
- Episodes from past 1992 are never shown.
- When first-run episodes of "Garfield and Friends" aired on CBS from 1988-1994, the program was in a one-hour format. In syndication, it airs in a half-hour format, with two "Garfield" segments, one "US Acres" cartoon, and a "Garfield Quickie" to conclude the show.
- The US DVD release uses the original openings, but also uses the 30-minute format and the UK "Orson's Farm" logo (although the segments are still listed as "U.S. Acres" in the credits)
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