The amount of Guinness in Dr. Hirsch's glass at the pub keeps changing.
When Gerald Bringsley first sees the werewolf in the tunnel, he makes a right turn with the camera behind him (the view is the werewolf's). When the camera view switches to be in front of Gerald, he's emerging from a left turn.
At the beginning sequence, after he left the car with the sheep, David has dirt on his jacket. At the next scene, only a few seconds later, the dirt has gone.
At 28.22 when Nurse Price suggests force feeding David a second time she only has some meat on the fork but the next cut she has meat and potato on the fork.
In the pub scene, the level of the beer in the glasses changes.
Repeated mentions of werewolf attacks during a full moon are ignored when David undergoes his transformation on two consecutive nights. There is only one full moon during a lunar cycle. If the moon is full on a Saturday night, for example, it cannot be truly full on the next night, Sunday.
At the film's end, Alex is standing a few feet away from the werewolf. Several police officers are about 50 feet away and directly behind Alex. Somehow, they shoot several times, inflicting fatal wounds to the werewolf without hitting Alex once. She is too close to the werewolf and between the werewolf and the police to not have been hit herself.
After his initial transformation, how does werewolf David get out of the apartment? He can't work the door, and given the cold weather, he's unlikely to have a window open. David had both the door to the flat and the door to the living room open sometime before he transformed and never closed them.
It would seem extreme to take a badly injured patient all the way from Yorkshire to London - a journey of some 200 miles - when St James' Hospital in Leeds would be a lot closer. That is, unless the parents requested their son be taken to a hospital in London, due to ignorance of UK geography or assuming a hospital in the capital would provide the best treatment. Either that, or the locals felt it would be much safer to get David as far away from them as possible.
When Doctor Hirsch is reading the newspaper about the murders, the first paragraphs of the news story relate to the murders, but the following paragraphs (in smaller font) relate to a completely different story (demonstrations by the New National Front).
When David and Jack are walking on the moors, their shadows are always in front of them, despite them having changed direction numerous times. Additionally, with the moon always being behind them, how are their faces being lit?
When Gerald falls on the tube escalator running from the Werewolf you can clearly see the station clock displaying 13:01 despite the scene being an evening one under a full moon.
In the final scene, an RT bus is shown as being in-service in Piccadilly Circus. In fact, the last RTs were withdrawn from service in London in 1979.
When Jack is in his final state of undeath in the porno theatre with the rest of the people that David killed, he uses a lot of words that are formed with the lips, such as 'schmuck'. However, Jack is virtually skeletal and has no lips to form the words.
In the Slaughtered Lamb when David and Jack order tea, the conversation resumes around the room. The noise sounds like 30 people speaking, but in two shots there aren't any mouths moving.
When the werewolf is seen approaching the escalator in the Tottenham Court Road underground station, a foot of one of the crew pushing the werewolf along is clearly visible at the end of the shot.
The couple in the street are the first to be attacked by the werewolf in London. As they walk in the street past the houses, a large studio light is reflected in the windows.
In the opening scenes, David and Jack reveal they are in northern England, and all the locals speak with Yorkshire accents. Yet the terrain is far too mountainous for Yorkshire (the scenes were filmed in Wales).
The distance from the Yorkshire moors to London is approximately 250 miles. It would be next to impossible for Dr Hirsh to do the 500-miles round trip in a day - even without taking into account the fact that doctors can't suddenly miss a day's work on a whim.
Jack haunts David because David was attacked by the werewolf, and Jack can't rest until the werewolf's bloodline is severed. After David (as a wolf) kills the six Londoners, they haunt him too. But Jack is the only one killed by the previous werewolf who haunts David, even though the previous werewolf must have killed more than one person.
Dr. Hirsch asks David "Do you remember anything about the man who attacked you?" David responds, "Dr. Hirsch, it wasn't a man, it was a wolf". Dr. Hirsch then says, "Well, maybe it will come back to you." David responds, "There's nothing wrong with my memory." Except, there is something wrong with his memory since he doesn't remember the man (werewolf in human form) on the ground next to him, naked and bleeding, where the werewolf used to be after it got shot.
The orderly explains that David is being served toast and jam. However, in subsequent shots, it is obvious there is no jam on any of the toast.
David asks Jack, "What shall I do?" and "How shall I do it?" These constructions are atypical of American English, wherein "shall" is rarely used in conversation. Native American speakers would typically ask, "What should I do?" and "How should I do it?" The use of "shall" reflects a more formal tone, typical of British or legal contexts, making it inconsistent with David's American background.
When David is in the phone booth and is contemplating committing suicide by slashing his wrist, he's holding the knife to his wrist the wrong way.