- Theme From Doctor DetroitWritten by Mark Mothersbaugh and Gerald Casale (as G. V. Casale)Performed by DevoDevo produced by DevoDevo appears courtesy of Warner Bros. Records, Inc.
- Super FreakPerformed by Rick JamesCourtesy of Motown Records
- Luv - Luv
- Hold HimPerformed by Pattie Brooks and Dan AykroydCourtesy of Backstreet RecordsPattie Brooks appears courtesy of Mirage Records
- Working GirlsPerformed by Pattie Brooks and Dan AykroydCourtesy of Backstreet RecordsPattie Brooks appears courtesy of Mirage Records
- You Are The OnePerformed by Pattie BrooksCourtesy of Backstreet RecordsPattie Brooks appears courtesy of Mirage Records
- Yo SkridlowPerformed by T.K. Carter and Dan AykroydCourtesy of Backstreet Records
- Bustin' LoosePerformed by Chuck Brown and The Soul SearchersCourtesy of Source Records
- Get Up Offa That Thing / Doctor DetroitPerformed by James BrownCourtesy of Backstreet Records
- King Of SoulPerformed by James BrownCourtesy of Backstreet Records
- Get It On And Have A PartyPerformed by Pattie BrooksCourtesy of Backstreet RecordsPattie Brooks appears courtesy of Mirage Records
- Doctor Detroit soundtrack album produced by Ira Newborn and Robert K. Weiss
- Original soundtrack album avaliable on Backstreet Records and Tapes
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