The movie was filmed during the Fall of 1965 with Mike Henry experiencing so many traumas (Chimp bite, infections, etc) that by January 1966 he quit the Tarzan movie series. The movie was shoved to the side for two years to work on the 1966 TV series as well as the release of "Tarzan & The Great River" (1967). This meant that young actor Steve Bond (The Jungle Boy) had aged from 12 to 15 by the time the movie was filmed and released for the big screen.
Nagambi and Buhara were played by real life brothers Gold medal winner Rafer and Edward Johnson.
This is the last "Tarzan" film to take place in the present day.