The show was so successful that it aired on all three major networks. It aired first run on CBS until 1975. Reruns aired on ABC in 1975-76 (later replacing Uncle Croc's Block), then on NBC, replacing the canceled McDuff, The Talking Dog, from November 27, 1976 until September 3, 1977 (thus completing the cycle of being on all three networks). It was then picked up by the USA Network for their Cartoon Express shows from 1982 to about 1990. Like most cartoon series produced by Hanna-Barbera in the 1970s, Speed Buggy contained a laugh track (later removed for repeats on Cartoon Network and Boomerang).
Speed Buggy and the gang guest starred in a October 13, 1973 episode of The New Scooby-Doo Movies, "The Weird Winds of Winona"; it was the only time that Mark, a Native American, was shown in a darker skin color.
In 1975, Charlton Comics published a 9-issue Speed Buggy comic book series.
In the Johnny Bravo episode "Bravo Dooby-Doo", Speed Buggy makes a cameo at the end offering Johnny a ride after the Scooby Gang ties him to a tree and leave him there. He was voiced by Frank Welker, long after the death of Mel Blanc.
Although closely patterned after the meddling kids characters of Scooby-Doo, Where Are You!, some Speed Buggy episodes were actually reworkings of Josie and the Pussycats story lines, including Captain Schemo and the Underwater City ("The Nemo's a No-No Affair"), "Out of Sight" ("X Marks the Spot"), "Gold Fever" ("Midas Mix-Up"), "Kingzilla" ("Plateau of the Apes Plot"), "The Incredible Changing Man" ("Never Mind a Master Mind"), and "Island of the Giant Plants" ("A Greenthumb is not a Goldfinger"). Additionally, the episode "The Hidden Valley of Amazonia" was similar to the Josie and the Pussycats in Outer Space episode "Warrior Women of Amazonia".