William Gargan had originated the role of Martin Kane, Private Eye (1949) on radio and television in 1949. Gargan played the role for two seasons before leaving, but the show continued for three more seasons, with a different lead actor for each season. The other three actors who played Martin Kane were Lloyd Nolan, Lee Tracy, and Mark Stevens. Gargan returned to the role for one season in The New Adventures of Martin Kane (1957), a syndicated revival of the show, filmed on location in Europe, which featured Kane handling international cases in London and Paris.
The show's main character, Martin Kane, was named after a real-life executive at J. Walter Thompson & Co., the advertising agency that produced the original TV and radio show. After leaving the agency, the real Martin Kane became an editor for "Sports Illustrated."