While trying to get sponsors for this series, the producers approached the Volkswagen executives and showed them the pilot show which featured actual bombing footage from the war. During the film, one of the executives recognized the plant that was being bombed as the Volkswagen plant which had made cars for the German Army at the time. He commented, "There goes our plant", and the executives then and there decided not to sponsor the show.
While most of the airborne footage in the series was wartime combat footage, much of it from the documentary "Memphis Belle" directed by William Wyler, the former DB-17P 44-83584 (N3713G) at Edward T. Maloney's Air Museum at Ontario, California, was brought the short distance to the former Cal-Aero Field at Chino where the 918th Bomb Group flightline sets were and used for taxiing, crew loading and unloading sequences, and as a backdrop for other filming.
TV Guide said that the firing of Robert Lansing in 1964 generated the most letters they had received since the assassination of President Kennedy in 1963.
In season one, episode seven, "Decision", Brigadier General Frank Savage is sitting in the co-pilot's seat. This was the only time that this happened.
Parts of the soundtrack used on segues for Star Trek are also used for segues on 12 O'clock High.
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