Plot

Uday Gupta finds himself as the lone male resident in the Gynaecology department. His reluctance leads to chaos, confusion, comedy and eventually, great camaraderie with his fellow classmates.

Uday Gupta (Guddu) a medical student wants to take up Orthology but due to lack of seats he gets enrolled in Gynaecology for which he is least interested.He believes that Gynaecology is a subject made for females as most patients prefer female Doctors at the time of delivery.Due to lack of seats Uday has to enroll himself in Gynaecology where he has to face brunt from his senior female Doctors.Uday soon befriends his female colleagues one of them being Dr Fatima Siddiqui but he is still least interested in Gynaecology and still prefers to enter Orthology where he comes under radar of strict Dr Nandini Shrivastav.—alex.mjacko@gmail.com

Dr. Uday Gupta (Ayushmann Khurrana) is a medical student who has just passed his final M.B.B.S exam. He lives in Bhopal with his widowed mother Shobha (Sheeba Chaddha), an aspiring chef who hopes to make it big on social media through her cookery channels, and his best friend, Abhishek Chandel "Chaddi" (Abhay Chintamani Mishr), who is preparing for the civil services examination. Uday wants to pursue his post-graduation in orthopedics, inspired by his distant cousin Dr. Ashok Gupta (Indraneil Sengupta). His rank in the competitive entrance test, however, is insufficient for an orthopedics course in Bhopal. Unwilling to leave his mother behind and move to another city for his studies, Uday reluctantly opts for the best available option in Bhopal-gynecology. He is asked by the counselor to convince a fellow student Priyanka (Sharvari Deshpande), who got Ortho, to swap seats with him. Uday begs Priyanka, that he and his girlfriend Ruchi have big plans after marriage (she will do Optho) and they will start a clinic together. Priyanka informs Uday that Ruchi is breaking up with him and storms off, refusing to swap her Ortho with his Gynae. Uday is also angry with Ruchi for spending way too much time with his study companion Vishal. Ruchi breaks up with Uday saying that he doesn't trust or listens to women.

Ashok also advises Uday to take this opportunity; Uday can simultaneously continue to study for next year's entrance test. Uday is introduced to Kavya Sharma (Ayesha Kaduskar), a high school student who also aspires to become a doctor and whom Ashok is infatuated with.

Uday's initiation into Gynaecology starts on a bad note-he is instantly ticked off by the head of the department, the strict Dr. Nandini Srivastav (Shefali Shah), for joining the course 10 days late, and he gets bullied by his colleagues, all of whom are female. Uday blames his ex-girlfriend Ruchi (Karishma Singh) for his present state and, egged on by Ashok, drunkenly calls her and vents his frustrations. Ashok asks Uday to apply for leave and study for next yr exams to get a better rank and get into Ortho. When Uday asks Nandini for leave, for his mother's heart treatment in Delhi, she tells him to bring his mother to their hospital and she will personally oversee her treatment.

His lack of interest at work and his mistakes at work irritate Nandini, who asks Uday why he doesn't want to become a gynecologist. Uday replies that male gynecologists tend not to do well because patients prefer a female doctor examining them. Nandini rubbishes this and asks him to lose his "male touch". Following this, Uday gradually befriends his colleagues (Dr. Jenny (Priyam Saha), Dr. Kumudlatha Pamulparthi Diwakaran aka KLPD (Shraddha Jain), Nurse Sunita (Puja Sarup)), especially his senior, Dr. Fatima Siddiqui (Rakul Preet Singh). Eventually, he falls for her and the two share a passionate kiss, although Fatima dismisses the act as nothing serious, reminding a disappointed Uday that while he is a good friend, she is set to marry the man she loves, Aarif (Paresh Pahuja). She also invites him to their engagement.

On a day the hospital is understaffed, Uday tries to examine a female patient without a female attendant, an act considered unethical. A fight breaks out and the patient and her husband Pappu Sahu (Devas Dixit) later formally complain against him. While facing a disciplinary inquiry, Uday performs his first delivery in the hospital (as an emergency case), a case of precipitate labor. The girls celebrate with Uday, but Nandini yells at Uday for not checking on the woman on time. She wants to know why Uday shies away from checking a vagina, and this almost endangered a woman's life today. The grateful family, who had lost two pregnancies before, name the baby after him. Uday finally understands his duty as a doctor towards his patients. At the inquiry, testimonies of Uday's colleagues clear his name. Nandini, though, remains unimpressed.

Uday tries to confess his love to Fatima at a dinner date, but Shobha's entry complicates things (Shobha was there on a tinder date, and calls Fatima as Uday's girlfriend) and Fatima storms off. Meanwhile, Ashok has got Kavya pregnant and needs to get an abortion. A prominent doctor and married with two children, Ashok cannot go with Kavya to a hospital himself, so he asks Uday to take her. Check-ups by Fatima reveal that Kavya has Placenta Praevia (Kavya is 16 yrs old, but lies that she is 18 yrs old as instructed by Ashok), making abortion difficult. Nandini refuses when Uday requests her to perform the operation herself, stating that it might threaten Kavya's life and thus her family should be informed first. she advises Uday to take Kavya to a shelter outside the city, where she can deliver the baby in secrecy. Ashok asks Uday to keep Kavya at his home for the time being, and the two bond well. Kavya tells him that she had first doubted Ashok's character the day he had encouraged Uday to call and rant against Ruchi; Uday feels ashamed of his past behavior.

On the day of the engagement, Ashok calls Uday and tells him to take Kavya to his clinic, because he has "come up with a solution". Arriving home, Uday is shocked to find Shobha partying with an elderly stranger, who turns out to be her Tinder date. Infuriated, Uday orders both the old man and Chaddi-who had helped Shobha get on Tinder in the first place-out of the house. When Uday claims that he has made sacrifices for her sake, Shobha snaps back, relating the difficulties she had raising him as a single mother. Now that her son has grown up, she now desires companionship. Mother and son then make peace.

Soon, Uday receives a call from Kavya-she is in intense pain after receiving an injection at a private clinic. He and Shobha rescue her and rush her to the hospital, where Nandini performs an emergency operation and saves her life. Ashok arrives at the hospital and confronts Uday, but he hits back. Since Kavya is a minor and below the age of consent, the matter is turned over to the police, who arrest Ashok for statutory sexual assault. Uday again has to face an inquiry, and possible rustication, for lying to Nandini about Kavya's age earlier. Nandini, however, sees that Uday is now a changed man (when Kavya wakes up and thanks Uday for saving her life), and decides against punishing him. An overjoyed Uday rushes to Fatima's engagement, and proposes to remain her true friend forever.