This is deep, maybe it's too dark and people are not ready to hear about these subjects in a humorous way, but like he says in it it's important that humorists can talk about controversial subjects. It's important that people can find humour even in the darkest things. I've never seen Dave as open as he is here, he takes risks and it might not talk to your preconceived ideas on sexual equality, racial equality or whatever else you don't agree with him, maybe you'll think he's crude, but it's just an access to the mind of a comedic genius who tries to make sense of the world he lives in with all it's absurdities.
The small intimate setup is perfect for this type of monologue, the proximity with the public procure the intimacy needed to talk of those subject without making it feel disrespectful.
One of the most intelligent show I've seen.
When we look back at 2017-2018 in 20 years, this might be a good insightful moment to look back on in all the craziness.