This is part of the Wasteland Saga from Jonni Phillips, with it centering around Lillith. This short touches me forever on so many different levels, from the sharp comedy of the Scrumbos (a teletubby ripoff) to the long scribbly sequences of Lillith descending further into a depression. There is an abundance of thought and intention with every single piece of the plot and the commentary about art's place in capitalism moves in step with those. I also personally adore the soundtrack and the use of sound in the animation (lots of tuba-esc noises with motions and zooms).
If you want an animation that is truly "adult" in that it is willing to give you those more in depth and complex experiences, please check this out. I cannot express enough that this is one of, if not, my favorite animated pieces ever.