The vast majority of the cast of previous Lego Marvel games did not return for this game, due to a voice actors' strike. The strike was organised by SAG-AFTRA and backed by a number of other worldwide unions, and related to residuals and other conditions.
A minifigure version of Howard the Duck says he wishes he had a video game since he's never had one. This isn't actually true, as there was a Howard the Duck game in 1986.
At the party in Avengers Mansion, Captain Marvel says "the brie is fantastic", a reference to Brie Larson, the actress who portrays Captain Marvel in the Marvel Cinematic Universe
This video game was released when the MCU's The Infinity Saga (2008-19) was due to end with Thanos being the main villain and hinting what's about to happen in the MCU's The Multiverse Saga (2021-26) with Kang as the main villain.