Plot

A famous fortune teller who claims to be spiritually linked to Marie Antoinette and calls herself 'Madame Antoine' goes head-to-head with a cold psychotherapist who runs a clinic also by the name 'Madame Antoine' and aims to prove that true love doesn't exist.

Go Hye Rim (Han Ye Seul) operates the Madame Antoine cafe on the first floor of a building that also houses a famous psychotherapy clinic on the top floor. Hye Rim uses her keen intellect and heightened senses to also work as an adviser to psychotherapist Choi Soo Hyun (Sung Joon). But unknown to Hye Rim, Soo Hyun is running a top-secret experiment on her "ideal type of man" with the help of his younger half-brother, Choi Seung Chan (Jung Jin Woon), and clinic employee Won Ji Ho (Lee Joo Hyung). But unknown to Soo Hyun, Hye Rim also is being paid by a mysterious man to get a hold of Soo Hyun's valuable experiment files. What is Soo Hyun's true experiment, and will Hye Rim help him or hurt him in his research goals?

When a clinical psychologist moves upstairs to a sham psychic, they realize they can both read everyone but each other. Choi Soo Hyun decides he will be the third suitor in his psychological experiment. Hye Rim's ex-husband shows up and forces her to drop her emotional shield. When famous singer Ju Ni starts having panic attacks, Soo Hyun tries to cure her despite her prickly personality. When Lee Kyung Joo returns to confront Soo Hyun, Hye Rim begins to figure out what is happening to her. Soo Hyun fears his emotions are sullying his experiment, and pulls himself out of it. A new patient walks into the Madame Antoine clinic with multiple personality disorder. Hye Rim must decide if all of her misgivings are real warnings or just her own defenses pushing a good thing away. As Soo Hyun tries to cement his relationship with Hye Rim, he also continues with his experiment. Seung Chan and Ji Ho come clean, turning the experiment on its head. Hye Rim decides she's going to fight fire with fire, and a mysterious woman shows up to get a consultation. Soo Hyun tries to treat a former friend of his who has stolen his identity. Soo Hyun knows the most important part of his experiment, but struggles to put it into action. Bae Mi Ran wants to keep her feelings a secret, but that isn't easy either. After the secret is out, Soo Hyun does everything he can to get Hye Rim to understand his feelings were pure. Seung Chan ticks off events from Mi Ran's bucket list, but with a caveat. In the finale, the tables are turned and it is Hye Rim who must take the role of counselor to help heal Soo Hyun.