This show is simply amazing, it has great writing, superb acting, unpredictable storylines, deep and interesting themes, great attention to details, and amazing pacing, it's the best show when it comes to using a 22 episode season without being full of filler.
The characters on this show are quite well written, they feel, talk and act like real humans , I care about all of them to some extent..in fact, I might be more invested in their lives than I am my real friends..oops! It's not only the main characters though, I often find myself really loving characters that only show up for few episodes, all the props to the writers and the cast.
Now the show isn't perfect, it does take some time to gain momentum, the first season while enjoyable is rather slow compared to the rest of the show. also the show tends drop storylines or leave some things unexplained, that doesn't bother me personally, but might bother others.
There is also the connections to the rest of the MCU, which some people see as not enough, others too much, and yeah it can be a bit frustrating when the crossovers you imagine don't come through, but it's not something I'd hold against this show, I think they write around the MCU well enough, all things considered. In fact, I like that the show adds a 3rd dimension to the movies, It is more interesting to me than characters showing up for a quick team up or the like.