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In the dimly illuminated medical realm of 19th-century Vienna, a pioneering film arises to chronicle the incredible story of Ignaz Semmelweis, a Hungarian doctor who dared to defy medical convention. Directed by Lajos Koltai, “Semmelweis” depicts a watershed moment in medical history that would ultimately save many lives.

Set in 1847, the film transports viewers to a bleak medical scene in which maternity wards were feared as death factories. Miklós H. Vecsei presents Semmelweis as a passionate and driven young doctor working at Vienna General Hospital, where an unexplained tragedy occurred. Puerperal fever, an unknown murderer of new moms, terrified pregnant women so much that they would prefer to give birth on the street than visit a hospital.

A pregnant woman screaming on the street, afraid of the hospital’s lethal reputation, is the opening scene of the film that best illustrates this horror drama. Semmelweis started a research that would become revolutionary.

The scream that pierces through the opening of “Semmelweis” sets the tone for the 19th century-set drama from Lajos Koltai, about the groundbreaking Hungarian obstetrician Ignaz Semmelweis, immediately showing its concern for a very pregnant young woman desperately roaming the streets for a proper place to give birth. Loath to check in to local clinics that have acquired a reputation for patients mysteriously dying in postpartum care, her shaken faith in the health care system sets a distinctly modern emphasis for the sturdy, old-fashioned Vienna period piece, selected as Hungary’s official Oscar selection after it became a local box office hit.

Even without taking a look at a picture of the real balding and bespectacled Dr. Semmelweis, it’s immediately clear Koltai wants to deliver something that’s more popcorn than medicinal when he gives a movie star entrance to the dashing Miklós H. Vecsei, playing the film’s title role.

It’s been more than 15 years since Oscar-nominated cinematographer and director Lajos Koltai helmed his last film, “Evening” (2007), a poignant meditation on mortality, regret and womanhood that featured a star-studded ensemble cast, including Vanessa Redgrave, Glenn Close, Eileen Atkins and Meryl Streep, and was released domestically by Focus Features.

For his return to the director’s chair, the Hungarian-born filmmaker also returns closer to home with “Semmelweis,” a period biopic drama about a Hungarian doctor who turns the medical establishment on its head in 19th-century Vienna. The film opens the 21st Hungarian Film Festival of Los Angeles, which runs Oct. 27 to Nov. 2 at the Laemmle Monica Film Center.

“Semmelweis” is set in 1847, as a mysterious epidemic is raging in a maternity clinic in Vienna. The film follows the Hungarian-born doctor Ignác Semmelweis, played by rising Hungarian actor Miklos H. Vecsei, in a race against the clock to solve the mystery...

South by Southwest, the multi-faceted film, music and technology festival held annually in Austin, TX will feature such upcoming films as Paul Feig’s Spy, David Gordon Green’s Manglehorn, Alex Gibney’s documentary Steve Jobs: The Man in the Machine, and Ondi Timoner’s Russell Brand profile Brand: A Second Coming as headliners in this year’s film festival lineup.

SXSW runs from March 13 to 21 in Austin and is now in its 22nd year. Variety has details of the 145 films and 100 world premieres bowing at this year’s festival. Brand, as previously reported, will be the festival’s opening night film.

Other notable titles on the list are the Will Ferrell/Kevin Hart comedy Get Hard, a rough cut of Judd Apatow’s Trainwreck, the directorial debut of 28 Days Later screenwriter Alex Garland, Ex Machina, and a new comedy by Michael Showalter, Hello, My Name is Doris.

On the small screen,...