- Became the 21st host on The View (1997) right around the time the show turned twenty one. She had initially turned down the job offer until her dad Senator John McCain convinced her to change her mind.
- Met husband Benjamin Domenech on Twitter.
- Her grandmother Roberta McCain celebrated her 107th birthday (February 7, 2019). She was just 68 days old when the Titanic sank (15 April 1912).
- (July 19, 2019) Had suffered a miscarriage and was expecting a baby girl.
- Younger sister Bridget is adopted.
- Appeared (clothed) for an interview in the April 2012 issue of Playboy magazine.
- Her 5th grade English teacher was Erik Weihenmayer, the first blind person to reach the summit of Mount Everest [May 25, 2001].
- Is a huge fan of the horror movie genre.
- Release of her book, "My Dad, John McCain". (2008)
- First child, daughter Liberty Sage McCain Domenech, born. [September 28, 2020].
- Though she is a longtime registered Republican, she voted for Democrat John Kerry in her first presidential election in 2004, saying that she could not bring herself to vote for George W. Bush, as four years earlier during the Republican presidential primaries, when her father was a leading candidate, operatives linked to the Bush campaign spread rumors about her family such as claiming her mother Cindy was a drug addict and her younger sister Bridget, who was adopted from Bangladesh, was her father's illegitimate child.
- Originally planned to become a music journalist and interned at Saturday Night Live (1975) and Newsweek.
- Graduated from Columbia University with a degree in art history.
- Release of her book, "Dirty Sexy Politics". (August 2010)
- Counts Johnny Cash as one of her all-time favorite musicians.
- Phoenix, Arizona (September 2010)
- Columnist, The Daily Beast.
- Close friend Janice Dean attended Meghan's November 2017 wedding.
- (November 21, 2017) Married her longtime boyfriend Benjamin Domenech just before sunset at her family ranch in Sedona, Arizona following a 4-month-long engagement.
- Fox News contributor.
- As a 21-year-old, Meghan once interned for Pulitzer Prize-winning biographer Jon Meacham when he was editor-in-chief of Newsweek.
- (March 22, 2020) Expecting her first child with husband Benjamin Domenech.
- Sister-in-law of Ellis Domenech and Emily Domenech.
- Counts conservative political commentator S.E. Cupp as one of her nearest and dearest friends.
- Is a Pro Life advocate.
- Is close friends with actress Barret Swatek.
- Resides in the same Manhattan apartment building as Full Frontal with Samantha Bee (2016)'s co-writer Kristen Bartlett [2020].
- CBS TV personality and family friend John Dickerson performed the ceremony at Meghan and Benjamin Domenech's Arizona wedding (November 2017). Meghan's wedding gown was designed by Georgina Chapman and Keren Craig of New York's elite "Marchesa" womenswear.
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