- First celebrity to grant 500 wishes through the Make a Wish Foundation.
- Before he became a professional wrestler full time, he was a struggling voice actor.
- Is best friends with wrestlers Randy Orton and John Hennigan off-camera.
- Good friends with Sacha Baron Cohen.
- His wife Liz was his high school sweetheart. They became engaged in September 2007.
- Has made a suggestion to WWE Films that they team up with Disney to do a film version of Dave the Barbarian (2004), with himself playing the title character.
- Is the second oldest of five brothers born to Carol Frances (Lupien), from Vermont, and John Cena Sr. (John Joseph Cena). He was raised in West Newbury, Massachusetts, where he played college football. Cena is a cousin of "Tha Trademarc" Marc Predka. He attended Springfield College in Massachusetts, graduating with a degree in exercise physiology and movement studies.
- Writes his own raps
- Sometimes known as "The Marky Mark of Wrestling".
- His paternal grandparents, Felix Joseph Cena and Caterino Ann "Catherine" DiVincenzo, were of Italian descent. His father has roots in Livorno in Tuscany and Lazio. John's maternal grandfather, baseball player Ulysses John "Tony" Lupien, Jr., was of French-Canadian descent, with deep roots in Québec, and his maternal grandmother, Natalie Nichols, was of Colonial American (English) ancestry, with roots in Massachusetts going back to the 1600s.
- His last name is the Spanish word for "dinner".
- Replaced Danny Cooksey as the voice of Dave in the Disney animated series Dave the Barbarian (2004), but the show was canceled before any new episodes aired.
- John Cena played the piano cover of Mötley Crüe's "Home Sweet Home" in Episode 6 of the HBO Max series Peacemaker.
- Used to be known as Prototype before starting with the WWE
- Teamed up with Randy Orton to face the whole WWE roster since Paul Levesque (aka Triple H) was general manager for the night.
- Engaged to Nikki Garcia from April 2, 2017 to April 15, 2018.
- Sported his own version of the WWE United States Championship Belt. The front plate had a sparkled red/blue background with "US" in big white letters. The center plate spun round like a turntable.
- Former Wrestling Tag Team Champion with Rico Constantino and Ohio Valley Wrestling Heavyweight Champion.
- Was booked to be the 2003 King of the Ring before WWE decided to cancel the tournament for that year.
- Earned $8 million from the WWE for 2016.
- Was involved in the only two instances when the holder of a "Money In The Bank" contract (which guarantees the contract holder a match for the Heavyweight or WWE Championship at a time and place of their choosing within 12 months of winning the contract) failed to capture the championship. The first time, Cena was the challenger who "cashed in" the contract but failed to capture the title (he won the match via disqualification, but championships don't change hands under such circumstances), and the 2nd time, he was the champion and successfully defended the title by pinning the challenger. In all other cases, whoever held the "Money In The Bank" contract was able to "cash in" the contract to successfully capture the title, and winning the contract is generally seen as a guaranteed title reign down the road.
- November 23rd 2008 - won his first World Heavyweight Championship after defeating Chris Jericho at Survivor Series, his first match back from surgery for a herniated disc in his neck, an injury he picked up at Summerslam, in a match he lost to Batista.
- On July 18, 2021, John Cena returned to the WWE at the "Money In The Bank" pay-per-view event.
- Usually wears knee-high denim shorts with a throwback and cap.
- Has flown back to Australia to continue filming of 'The Marine'. (December 2004)
- On April 2, on an edition of RAW, he & Shawn Michaels lost the World Tag Team Championships to Jeff & Matt Hardy in a Tag Team Battle Royal due to Shawn Michaels dumping him over the top rope. (April 2007)
- Lost WWE Championship to Rob Van Dam at ECW One Night Stand. (June 2006)
- Defeated Jesus (Pronounced Hay-Zeus) at WWE Armageddon in a street fight to retain his United States Championship. (December 2004)
- Lost to Kurt Angle at Unforgiven by DQ so kept his WWE title. (September 2005)
- Defeated Booker T to tie their series of 5, 2-2. The deciding match will most likely take place at WWE No Mercy 2004. (September 2004)
- Defeated Triple H during Wrestlemania 22; kept the Championship belt. (April 2006)
- 2001 PWI Wrestling Rookie of the Year, 3rd runner-up.
- Former World Tag Team Champion.
- Won the 21th Royal Rumble Match (January 2008)
- Will face the number 1 contender at Wrestlemania 22 in Chicago, Illinois for the WWE Championship. (February 2006)
- #2 on the PWI top 500 wrestlers list in 2005.
- Won the WWE title back from Edge at the Royal Rumble. (January 2006)
- 4th August 2008, along with Batista, won the World Tag Team Championhips on Monday Night Raw, defeating Ted DiBiase & Cody Rhodes after Batista pinned DiBiase- this is Cena's 2nd World Tag Team Championship, Batista's 3rd.
- Will be facing Edge in a match for the WWE title on a special Thursday night Raw with Mick Foley as guest referee. (February 2006)
- Defeated Booker T at Summerslam 2004 with the FU to win the first match in the Best of Five Series for the WWE U.S. Title. (August 2004)
- Successfully defended the WWE Championship inside the Elimination Chamber at New Year's Revolution. But shortly after, Edge cashed in his Money in the Bank contract, allowing him to face Cena for the title. In about 2 minutes, Edge finished off Cena with 2 spears and got the victory, therefore winning the WWE Championship. (January 2006)
- At the Royal Rumble he defeated Umaga in a Last Man Standing match retaining the WWE Championship. (January 2007)
- Former Ohio Valley Wrestling Tag Team Champion with Rico Constantino.
- Lost the United States Title to newcomer Carlito Caribbean Cool in Carlito's debut match. (October 2004)
- Beat Randy Orton on WWE Raw so he can face Triple H and Randy Orton at WWE Wrestlemania 24.
- Wrestles on WWE SmackDown! (January 2004)
- Stripped of The WWE Title after being injured in a match against Randy Orton. Orton then became the WWE Champion as a result of being the #1 contender.
- Will defend his WWE title against Eric Bischoff on the RAW homecoming on October 3rd. (October 2005)
- Will face Booker T at Summerslam 2004 in the first match of a Best of Five series to determine the undisputed WWE U.S. Champion, since he never lost the belt. It was stripped from him by former Smackdown GM Kurt Angle, when twice John Cena accidently hit the "injured" GM. (August 2004)
- Is set to face the Game, Triple H and the legend killer, Randy Orton in a Triple threat Match for the WWE Championship at the Grand-daddy of'em all, Wrestlemania 24 (March 2008)
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