- Third Baseman for Chicago Cubs (1960-1973) and Chicago White Sox (1974).
- Named to 9 National League All Star Teams (1963-1966, 1968-1969 and 1971-1973).
- Played with the Chicago Cubs (1960-1973) and Chicago White Sox (1974), batted .277 with 2,254 hits and 342 home runs.
- Lost both legs in 2002 to diabetes.
- Made major league debut on 26 June 1960.
- In 1964 led National League hitters in triples (13).
- Led the National League in bases on balls in 1964, 1966-1968.
- During the early years of his career with the Cubs, he carefully concealed the fact that he suffered from Type 1 Diabetes. He feared that had that information come out, he would have been forced to retire.
- Was a fan of Dawson's Creek (1998).
- Father of Jeff Santo.
- He is survived by his wife, Vicki Santos; four children; and his grandchildren.
- Inducted into the National Baseball Hall of Fame in 2012 (announcement of election by Veterans Committee made 5 December 2011).
- WGN Radio color analyst for the Chicago Cubs. (July 2004)
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