- Was hit by a bus during filming of a TV stunt. The stunt called for Nicholas to be tied to a chair and suspended 20ft off the ground when he was struck by the double decker which was supposed to stop inches from him. He escaped with a bruised head.
- Admitted on Top Gear (2002) that while wearing his full costume as Beast from X-Men, he ran onto a golf course, gave the golfers advice on their swing, and then simply ran away again, with no explanation.
- He was considered for the role of Bruce Wayne/Batman in The Batman (2021) and was the only actor besides Robert Pattinson to be seriously considered for the part.
- Was given a PlayStation, one of his character's jackets and his character's hamster by directors Chris Weitz and Paul Weitz after filming of About a Boy (2002).
- He has worked since the age of eight in film, television and theatre.
- Bought a bike with his earnings from About a Boy (2002).
- Was in an on-off relationship with American actress and X-Men co-star Jennifer Lawrence for five years.
- Gabriel Byrne gave him a watch at the end of filming Wah-Wah (2005), engraved with his name, just as his character did in the film.
- Was a choir boy.
- Has two kids with his partner Bryana Holly.
- Has three siblings: Clarista Hoult (b. 1992), Rosanna Hoult (b. 1984) and James Hoult (b. 1977).
- Used to play the trombone.
- Had to attend an audition for About a Boy (2002) wearing his school uniform but, unfortunately, he forgot his shoes. He told reporters that he borrowed his mother's white shoes and coloured them in, however, the colour came off.
- His father was an airline pilot and his mother a stewardess when they first met.
- He attended Sylvia Young Theatre School, a prestigious stage school in London.
- Left the Sylvia Young Theatre School to attend Ranelagh School, a local church secondary school.
- He was born on the same day as X-Men: First Class (2011) co-star Caleb Landry Jones: December 7, 1989.
- Enjoys playing basketball.
- For his role as an American in The Weather Man (2005), he was coached by Joan Washington, wife of Richard E. Grant who directed him in the film Wah-Wah (2005).
- He is the son of Glenis Hoult (née Glenis J. Brown), a piano teacher, from Rochford, Essex, and Roger K. Hoult, a pilot, from Birmingham, in the West Midlands. His patrilineal ancestry can be traced back to his four times great-grandfather, Joseph Hoult, who was born c. 1815, in Staffordshire, England.
- As of 2019, he has appeared in two films nominated for Best Picture, Mad Max: Fury Road (2015) and The Favourite (2018). Neither of which won.
- At one time, he was rumoured to be Eoin Colfer's favourite to play the lead role in the proposed "Artemis Fowl" film adaptation of Colfer's fantasy novel. However, as time passed and there was trouble producing the film, Nicholas grew too old for the role and, finally, the project was cancelled, altogether.
- Attended Farnborough Sixth Form College, located in Hampshire, in 2006-8, where he sat his AS and A-Level exams.
- His great-aunt was Dame Anna Neagle and his great uncle was Herbert Wilcox.
- He was the last guest star on Top Gear (2002) before the dismissal of Jeremy Clarkson and the quitting of James May, Richard Hammond, and Andy Wilman.
- Was originally supposed to star as Young Herman in El cerco (2005) but after production delays Thomas Brodie-Sangster was cast instead.
- Was invited to join the actor's branch of the Academy of Motion Picture Arts & Sciences in 2023.
- He was named ambassador for the Reading Rockets basketball club, a team with which he played in the British Basketball League (BBL).
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