- In 1965, Grimes made headlines after she had been beaten and injured twice in four days by what were described as "white racists". According to a report, Miss Grimes said she believed the attacks were related to her association with several black entertainers and recent appearances in public with Sammy Davis Jr. who was said to be staging a nightclub act for her.
- Mother, with Christopher Plummer, of Amanda Plummer.
- She named her daughter Amanda Michael Plummer (born in 1957) after her character in Noël Coward's Private Lives.
- Originated the title role in the Broadway production of "The Unsinkable Molly Brown".
- Replaced E.G. Marshall as the host for the "CBS Radio Mystery Theater" in 1982 (the final season of the program).
- Tried out for the 1952 free-style Olympic swimming team, but just missed out.
- Was originally offered the role of "Samantha Stephens" on Bewitched (1964); she turned the part down in order to concentrate on her stage career. Elizabeth Montgomery was cast instead. She did work with Dick Sargent (the second "Darrin" on Bewitched (1964)) on The Tammy Grimes Show (1966).
- Won the Best Supporting Actress Tony Award for playing the lead role in "The Unsinkable Molly Brown" because her name was not 'big' enough to appear on top of the title. According to Tony rules at the time, performers whose names appeared before the title were judged in the lead acting categories.
- Has won two Tony Awards on only two nominations: in 1961 as Best Supporting or Featured Actress (Musical) for playing the title character, Molly Brown, in "The Unsinkable Molly Brown;" and in 1970 as Best Actress (Dramatic), for a revival of Noël Coward's "Private Lives."
- Also won a Tony (In the correct category of Best Actress this time) when she played "Amanda" in "Private Lives" on Broadway in 1970. Other Broadway appearances include Neil Simon's play "California Suite" (1976), the musicals "High Spirits" (1964) and "42nd Street" (1980), and revivals of Molière's "Tartuffe" (1977) and Tennessee Williams' "Orpheus Descending" (1989).
- Studied acting at New York City's prestigious Neighborhood Playhouse under the guidance of legendary acting coach, Sanford Meisner.
- Grimes's mother, Eola Willard Grimes (née Niles; 1911-1989), a naturalist and spiritualist, published "Goodly Rapport and Affinity", a hardcover released in 1976.
- She was a lifelong liberal Democrat.
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