- At age 17, traveled to Europe and, in 1999, studied dramatic arts at the Central School of Speech and Drama in London, England for three years. He was the first Mexican to be accepted at this prestigious school.
- His favorite actor is Javier Bardem and would love to work with him in the future.
- As he is Mexican, he had to be able to do a convincing Spanish accent before Pedro Almodóvar would allow him to get his role(s) in the movie Bad Education (2004).
- Co-founder of the production company Canana Films [mx] along with childhood friend and fellow actor Diego Luna and Mexican producer Pablo Cruz. The company focuses on Mexican - and Latin American-themed features that deal with social justice issues.
- Became a father for the first time at age 30 when his (now ex) girlfriend Dolores Fonzi gave birth to their son Lázaro García on January 8, 2009 in Madrid, Spain.
- His parents owned a theater company.
- Close friends with Diego Luna. Friends with Mark Ruffalo.
- Was in a relationship with actress Dolores Fonzi. They met on the set of Privates Lives (2001) but they would not become a couple couple until 2008. They separated in 2014.
- His favorite actresses are Juliette Binoche and Emily Watson.
- Former boyfriend of Cecilia Suárez, Natalie Portman and Andrea de la Torre Suárez.
- Became a father for the second time at age 32 when his (now ex) girlfriend Dolores Fonzi gave birth to their daughter Libertad García Fonzi on April 7, 2011 in Buenos Aires, Argentina.
- Resides between Mexico City, Mexico and Buenos Aires, Argentina.
- Member of the 'Official Competition' jury at the 67th Cannes International Film Festival in 2014.
- Mentioned in the song "En el 2000" by Natalia Lafourcade.
- Named one of People en Español magazine's 25 Most Beautiful People of 2002 (June 2002 Issue).
- Member of the 'Official Competition' jury at the 57th Berlin International Film Festival in 2007.
- Was officially in the BAFTA longlist (Equivalently, the semi-finals) for Best Actor in a Supporting Role, for his role in Babel (2006), which consisted of 15 finalists for each category (except Animated Film). However, he was eliminated in the next round, which the five official nominees were selected [2007].
- Son of Patricia Bernal and José Ángel García. Half-brother of Dario Yazbek Bernal and Tamara Yazbek.
- Was ranked #7 on Entertainment Weekly magazine's '30 Under 30' the actors list. (2008)
- In a relationship with Fernanda Aragonés since 2018.
- Invited to join the Academy of Motion Pictures Arts and Sciences (AMPAS) in 2005.
- Chosen by Empire magazine as one of the 100 Sexiest Movie Stars in the World (#65). (2007)
- Was romantically involved with Belén Chavanne and Paloma Moreno.
- Anita Álvarez de Toledo is the godmother of his daughter Libertad García Fonzi.
- Ezequiel Díaz in the godfather of his son Lázaro Garcia.
- Has family from the same town as Fernanda Romero and Frank Miranda.
- Speaks Spanish and English fluently.
- Became a father for the 3rd time at age 42 when his girlfriend Fernanda Aragonés gave birth to their son Cosmo on September 30, 2021 in Mexico City.
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