- Middle of 3 sons of comedian Dom DeLuise and actress Carol Arthur.
- He and brother David DeLuise have both appeared in episodes of CSI: NY (2004). They also appeared in two episodes of Gilmore Girls (2000), in which they played brothers.
- Michael, his brothers Peter DeLuise and David DeLuise and their father Dom DeLuise have each appeared on Stargate SG-1 (1997) in various episodes.
- In Happy (1983), appeared with his father Dom DeLuise, his mother Carol Arthur and his two brothers, David DeLuise and Peter DeLuise.
- Appeared as a younger "Doug Penhall", played by his older brother, Peter DeLuise, in a flashback part of an episode of 21 Jump Street (1987).
- Shares a birthday with his mother, Carol Arthur.
- In SeaQuest 2032 (1993) in episode "Vapors" appeared with his brothers Peter DeLuise, David DeLuise, his father Dom DeLuise.
- Appeared on Stargate SG-1 (1997) in a reoccurring role. His father, Dom DeLuise, guest-starred in an episode, and his brother, Peter DeLuise, has cameoed on the show in addition to being a creative consultant and episode director.
- Can play the piano.
- Appeared on SeaQuest 2032 (1993) in episodes "Daggers: Part 1" and "Daggers: Part 2" with his older brother Peter DeLuise (who was one of the regulars) and his niece Riley DeLuise.
- Uncle of actress Riley DeLuise.
- Older brother of David DeLuise
- Accomplished oil painter. "Michael & Mom" 2011 Vermonts Arts Center - Gallery Show.
- Brother-in-law of actress Anne Marie DeLuise.
- He was once engaged to actress Sherrie Rose.
- Younger brother of Peter DeLuise
- Ex-brother-in-law of Gina Nemo.
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