- His brother, Daniel de los Reyes, is a percussionist who is a member of the Zac Brown Band and a former member of the bands Earth Wind & Fire and Chicago. He also has two sisters, Lily and Ilde, who reside in Las Vegas and work in the hotel business.
- Has twin sons, John Rubén de los Reyes and Michael Luís de los Reyes, born May 13, 2014. Children's mother is his wife, actor Sherri Saum.
- Chosen by "People" magazine as one of the 50 Most Beautiful People in the World. (1997)
- Had surgery on his right shoulder after suffering an injury while performing a stunt as Antonio on the set of One Life to Live (1968).
- Had a chance to visit the house in which his father grew up as a child in Havana, Cuba, while filming Love & Suicide (2005). The woman who lives there now is the daughter of one of his father's best friends and was featured in the movie. As it turned out, Kamar improvised an entire scene with her and halfway through the scene, she left and brought back a photo of Kamar's actual father Walfredo, which can be seen in the movie.
- Has twice been chosen by "People en Espanol" magazine as one the 25 Sexiest Bachelors (1997) (2005).
- Is proud of the fact that he had the opportunity to film a movie in the birthplaces of both his parents. Love & Suicide (2005) was filmed in his father's birthplace, Havana, Cuba; and Cayo (2005) was filmed in Puerto Rico, his mother's.
- His brother Walfredo Reyes plays percussion for Chicago.
- His mother, Matilde, resides in Ponce, Puerto Rico.
- His father, Walfredo de los Reyes, was born in Havana, Cuba, in 1933. it has been noted that Walfredo was one of the first trap drummers who added the tumbadora and bongo to the jazz idiom in the largest Antillean island.
- Attended high school with Lorenzo Fertitta and Dana White, co-founders of UFC (Ultimate Fighting Championship (2000)). They were juniors when he was a senior.
- Wife is actress and former One Life to Live (1968) co-star, Sherri Saum.
- Attended high school in Las Vegas with Charisma Carpenter. He was a junior when she was a freshman.
- Has a dog named Leo.
- De los Reyes appeared alongside Patrick Stewart as a "dashing, if thick-tongued" Ferdinand in a 1995 production of William Shakespeare's The Tempest.
- In 1995, de los Reyes starred with James Woods, Ed Harris and Sir Anthony Hopkins in Oliver Stone's controversial biopic, Nixon, playing convicted Watergate burglar, Eugenio Martínez.
- In 1997, de los Reyes was named on People Magazine's "Fabulous 50" list.
- In 2013, he played the role of Los Lordes gang leader, Santana in the two-part season finale of the third season of the CBS police procedural drama Blue Bloods.
- In 2012, he performed the voice acting and the motion-captured body acting of the main antagonist, Raul Menendez, in the video game titled Call of Duty: Black Ops II. The game's publisher Activision reports an estimated US$1 billion gross in its first fifteen days of availability, which the company states is superior to the seventeen day cinema record held by 2009's Avatar.
- Has one son, Caylen from a previous relationship.
- De los Reyes starred as a Chicano boxer named Pedro 'Roadman' Quinn, in 1994's acclaimed theatrical production of Blade to the Heat.
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