- She volunteers at a hospice for terminally ill children and works for the Audrey Hepburn Children's Fund.
- Is fluent in French and German.
- Son, Charlie, was diagnosed with Kawasaki Disease, #1 cause of congenital heart disease, in 2009.
- Can write with her toes.
- Close friend with Scrubs (2001) co-star Zach Braff.
- She has a brown Labrador named Lola, which the Scrubs (2001) cast bought her at a charity auction.
- She became a naturalized American citizen in April 2008.
- At times on the set of Scrubs (2001), Sarah is referred to as "Second Becky" in response to her being the second "Becky" on Roseanne (1988).
- When younger, played the cello for seven years.
- Sarah grew up in Vancouver, British Columbia.
- Since her mother is from Germany, Sarah visited a German school in Vancouver twice a week as a child.
- Her father is a lawyer and both her parents are mediators who also run a child adoption agency. Two years ago, she accompanied her parents to China to coordinate the adoption of several orphans there.
- Took over the role of Becky on Roseanne (1988) from Alicia Goranson in 1993.
- Gave birth to her 2nd child at age 39, a daughter named Frances Afifi on April 28, 2016. Child's father is her now ex-fiancé, Jamie Afifi.
- In her leisure time, Chalke prefers cooking with friends (especially Thai and sushi), playing the guitar, hiking, skiing (she's an instructor), snowboarding, kayaking and reading.
- Close friend with actresses Christa Miller and Nicole Sullivan.
- (1993-1997) Played older sister of Sara Gilbert on Roseanne (1988), but is younger in real life.
- Best health habit is wearing sunscreen every day. Lost her aunt to melanoma and her grandmother to cancer.
- Describes herself as a klutz.
- Played Markie Post's daughter in the horror film I've Been Waiting for You (1998) and Post also plays her mom as a guest star on Sarah's sitcom, Scrubs (2001).
- Appeared in local Vancouver theater productions, at age 8.
- When she was a few credits short of a college degree, she decided to commit to acting full time.
- She was previously engaged to entertainment lawyer, Jamie Afifi from December 2006 until September 2022.
- Said she would like to take a break from acting and attend college. (2001)
- Gave birth to her 1st child at 33, a son named Charlie Rhodes Afifi on December 24, 2009. Child's father is her now ex-fiancé, Jamie Afifi.
- Has competed in several walk-racing competitions.
- Has a younger sister named Piper Chalke and an older sister named Natasha Chalke.
- She has dogs named Harley and Tankers.
- She is vegetarian. Initially her father was not, but he eventually gave in due to family pressure.
- Attended the 1999 CCMA award ceremony, and presented an award for the best single of the year. (September 13, 1999)
- Her first on-camera kiss was in the 1992 movie City Boy (1992), shot at Lighthouse Park in Vancouver.
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