- She has a daughter named Barbara McLaughlin Kreutz. She was born in January, 1925. She died on November 20, 2003. She had a Masters Degree in Comparative Literature and PHD in History. She was Dean of the Graduate School of Arts and Sciences at Bryn Mawr. Irene's son, William McLauglin, was born in July, 1929.
- She has four grandchildren from daughter Barbara: Nicky, Gregg, Charlotte and Libby. She also has nine great grandchildren.
- In 1928, Castle founded "Orphans of the Storm," an animal shelter that still exists in Deerfield, Illinois.
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