- Calderón starred in Pirates of the Caribbean: At World's End (2007), playing one of the film's Pirate Lords alongside Rolling Stones band member Keith Richards. His character was Captain Eduardo Villanueva of the Adriatic Sea.
- During his career, Calderón worked with renowned director Sergio Leone on his penultimate film, the 1971 thriller Duck, You Sucker, and John Huston twice in The Bridge in the Jungle and Under the Volcano.
- The actor, who appeared in the Disney franchise as well as 1997 film Men in Black, had an acting career spanning six decades.
- Calderón was an American actor of Mexican descent.
- Calderón mainly played small roles in films, in the 1970s mainly in Spanish-language films, later also in American productions.
- His Instagram bio reads: "In love with life, passionate of the films I've made and the ones on the horizon. You might think I'm an Alien or a Pirate!".
- In Men in Black, his character is the one whose head appears on the end of a sword, which is brandished to Tommy Lee Jones's character, K, by an alien crossing the US-Mexico border line.
- After moving to Mexico City when he was 10, Calderón studied at the Instituto Andrés Soler of the Asociación Nacional de Actores.
- Sergio Calderón was the very first villain The A-Team faced, in the series' famous pilot episode. He later appeared again in a double episode.
- The Bridge in the Jungle was his first credit.
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