- Drea's father was a furniture manufacturer and her mother was a playwright. She was raised in Queens primarily by her grandmother and a Nicaraguan nanny. She now takes care of her nanny, who had a heart transplant.
- Her character on The Sopranos (1999) was originally written for only one episode.
- Speaks fluent Italian and Spanish.
- Gave birth to her 2nd child at age 39, a son Waylon Albert Jennings on April 7, 2011. Child's father is her now ex-fiancé, Shooter Jennings.
- Was in a relationship with Shooter Jennings from 2001 to 2013 and they also were previous engaged 2009-2013. They have 2 children together.
- Gave birth to her 1st child at age 35, a daughter Alabama Gypsy Rose Jennings on November 28, 2007. Child's father is her boyfriend (now ex-fiancé), Shooter Jennings.
- Lost her apartment home of 22 years, along with dozens of other residents, when a gas explosion and raging fire destroyed three East Village, Manhattan buildings on March 26, 2015.
- At NYU, she originally intended to study to be a director, but got attention for her acting.
- Graduate of NYU's Tisch School of the Arts.
- Paulo Costanzo, who plays her son on Joey (2004), is only five years younger than she is.
- Has her mother's, father's and grandmother's names tattooed onto her body.
- Has closed her clothing store Filth Mart in Manhattan and is opening one in Los Angeles
- Is of Italian descent
- Close friends with John Barrowman.
- Ranked #33 in Stuff magazine's "102 Sexiest Women in the World" (2002)
- She studied drama at HB Studio in Greenwich Village in New York City.
- Was engaged, in July 2015-2021, to Whitesnake bass guitarist Michael Devin.
- Her name is from the Greek name Andreas, which was derived from andreios "manly, masculine", a derivative of aner "man".
- Assault on Precinct 13 (2005) opened on her 33rd birthday.
- Endorsed Donald Trump for president in 2024.
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