- Older sister of actor Billy Zane.
- Speaks Greek fluently.
- Dated co-star Heath Ledger while they were filming Roar (1997).
- Lisa is a singer, BMI songwriter and recording artist. In 2006, the American Songwriters Hall of Fame recognized Lisa as one of their current songwriters of the year.
- Has Greek ancestry. Original family name is Zanekatos.
- Originated many roles on stage including Rita in "Prelude to a Kiss", and Cleo in "Robbers". Made her professional stage debut in David Mamet's adaptation of "The Cherry Orchard" at the Goodman Theatre in her native Chicago.
- Singer at Les Deux in Hollywood, California since 1997.
- Studied drama at Vassar College in Poughkeepsie, New York.
- Frequently sings in cabaret settings interpreting her material in their original language.
- Parents are William George Sr. and Thalia Zane.
- Ex-sister-in-law of Lisa Collins.
- She was considered for the role of Josephine Marcus in Tombstone (1993).
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