- Was one of the chorus of children who sang the theme song of The Electric Company (1971).
- His mother was doing a nightclub gig on a split bill with Josephine Baker in Copenhagen, Denmark, around the time he was born.
- His mother was an American opera singer and his father was a stagehand and carpenter from Naples, Italy.
- For a while in New York City, he was a roommate of Laurence Fishburne.
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6351 Hollywood Boulevard in Hollywood, California, on April 26, 2014.
- Speaks Italian and Spanish fluently.
- Lived in Europe, New York City, and Cleveland until he; his older brother, Vincent; and their parents moved to Manhattan when Giancarlo was six. During the boys' teens, the family lived in Elmsford in Westchester County, New York.
- Is a member of the Atlantic Theater Ensemble, the theater company started by David Mamet and William H. Macy.
- Practices yoga, and likes riding motorcycles and playing the saxophone.
- Won Obie Awards for his performances in "Zooman and the Sign" (1981) and "Distant Fires" (1993).
- Was a member of the dramatic jury at the 1997 Sundance Film Festival.
- Giancarlo Esposito and Aaron Paul appeared together many years before Breaking Bad (2008) on Fury (2006).
- He has appeared in three films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Desperately Seeking Susan (1985), Do the Right Thing (1989) and Malcolm X (1992).
- Is a supporter of Mumia Abu Jamal and participated in the 2012 documentary Mumia: Long Distance Revolutionary (2012).
- His last name is pronounced "ess-POSE-ee-toh".
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