32 wins & 27 nominations
- 2012 Nominee ALMA Award
- Favorite Movie Actor: Supporting Role
- 2004 Nominee Daytime Emmy
- Outstanding Performer in a Children/Youth/Family Special
For playing "Cruz".
- 1992 Nominee Primetime Emmy
- Outstanding Lead Actor in a Miniseries or a Special
For playing: "Ernesto Ontiveros". - 1991 Nominee Primetime Emmy
- Outstanding Supporting Actor in a Miniseries or a Special
For playing "Count Giuseppe Pepito Abatino".
- 2024 Winner Grammy
- Best Tropical Latin Album
For "Siembra: 45º Aniversario (En Vivo en el Coliseo de Puerto Rico, 14 de Mayo 2022)"Shared with: Roberto Delgado & Orquesta - 2020 Nominee Grammy
- Best Latin Jazz Album
For "Una Noche Con Rubén Blades"Shared with: Wynton Marsalis - 2018 Winner Grammy
- Best Tropical Latin Album
For the album "Salsa Big Band"Shared with: Roberto Delgado & Orquesta
- 2022 Nominee Image Award
- Outstanding Jazz Album - Vocal
Album: "Salswing!"Shared with: Roberto Delgado & Orquesta
- 2024 Winner CinEuphoria
- Merit - Honorary Award
Shared with: Michael E. Satrazemis · Austin Amelio · Dayton Callie · Keith Carradine · Zoe Colletti · Mo Collins · Cliff Curtis · Karen David · Alycia Debnam-Carey · Kim Dickens · Garret Dillahunt · Frank Dillane · Colman Domingo · Jenna Elfman · Christine Evangelista · Marlene Forte · Danay Garcia · John Glover · Maggie Grace · Lorenzo James Henrie · Colby Hollman · Peter Jacobson · Lennie James · Mercedes Mason · Colby Minifie · Daryl Mitchell · Alexa Nisenson · Daniel Sharman · Nick Stahl · Sam Underwood
- 2024 Nominee Latin Grammy Award
- Song of the Year
For "Aún me sigo encontrando" artists: Gian Marco & Rubén BladesShared with: Gian Marco · Julio Reyes Copello - 2024 Winner Latin Grammy Award
- Best Salsa Album
For "Siembra: 45° Aniversario (En Vivo en el Coliseo de Puerto Rico, 14 de Mayo 2022)"Shared with: Roberto Delgado & Orquesta - 2021 Winner Latin Grammy Award
- Best Salsa Album
For the album: SALSA PLUS!Shared with: Roberto Delgado & Orquesta - 2021 Winner Latin Grammy Award
- Person of the Year
- 2021 Winner Latin Grammy Award
- Album of the Year
For "SALSWING!"Shared with: Roberto Delgado & Orquesta · Oscar Marin
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