- Although he is probably best known for playing bully Biff Tannen in the Back to the Future (1985) trilogy, he is said to be a very nice man in real life who drew upon his own personal experiences of being bullied as a child to create the Biff persona.
- As a recurring character on Ghost Whisperer (2005), he returned to the same set he acted on during the Back to the Future (1985) trilogy.
- Was once roommates with Sam Kinison and Andrew Dice Clay.
- He was awarded the 1991 Saturn Award for Best Supporting Actor as Buford "Mad Dog" Tannen in Back to the Future Part III (1990).
- He paints many portraits of classic children's toys. He was selected to join the California Featured Artists Series at Disneyland (2006).
- Studied international business at Arizona State University in Tempe, Arizona.
- Attended and graduated from Radnor High School in Radnor, Pennsylvania (1977).
- Has three daughters (Anna May, Emily, and Grace) and a son (Thomas Francis III).
- Attended the American Academy of Dramatic Arts (AADA) in New York City.
- Is often mistaken by fans for the late character actor David Graf who played Tackleberry in the Police Academy movies. Many fans think Wilson played Tackleberry, unaware that it was in fact Graf and Graf actually passed away in 2001.
- He made guest appearances on both Lois & Clark: The New Adventures of Superman (1993) and Superman: The Animated Series (1996).
- Often received fanmail meant for Tom Wilson, creator of the Ziggy comic strip.
- Has appeared in an episode of the comedy series Psych (2006) entitled "Let's Get Hairy" and in a movie called Let's Get Harry (1986).
- Good friends with actor Marc McClure.
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