- Granddaughter of Bing Crosby and Dixie Lee
- Was 19 years old when her famous grandfather died, but never met him.
- Quit Star Trek: The Next Generation (1987) during its first season due to the fact that there were not enough "action" scenes for her character, Lieutenant Tasha Yar.
- Though her final appearance during the first season of Star Trek: The Next Generation (1987) was Skin of Evil (1988), the last episode she had filmed was Symbiosis (1988), which aired the week before "Skin of Evil". At the conclusion of "Symbiosis", as Patrick Stewart and Gates McFadden exit the Enterprise cargo bay, Crosby can be seen briefly in the distance waving goodbye to the camera before the doors close.
- Originally auditioned for the role of Counselor Deanna Troi, on Star Trek: The Next Generation (1987), but was hired as Lieutenant Tasha Yar instead.
- Born out of wedlock, her mother, Marilyn Miller Scott, sued her father, Dennis Crosby, for paternity in a highly publicized trial. The suit was filed only days after Crosby married a Las Vegas showgirl.
- The part of Sela, the alternate Tasha Yar's daughter who appears in Redemption, Star Trek TNG was conceived by Crosby who originally was to have had a daughter with Castillo on Romulus in the prison. The writers reworked it to be a Romulan daughter.
- Her family has worked with two generations of Clooneys. Her grandfather, Bing Crosby, appeared in White Christmas (1954) with Rosemary Clooney, and later toured with her in concert. Denise has appeared on Crossing Jordan (2001) with Clooney's son, Miguel Ferrer, who actually started his career as a drummer for Bing and Rosemary. Ferrer also appeared briefly in Star Trek III: The Search for Spock (1984), while Denise appeared on Star Trek: The Next Generation (1987).
- Distant cousin of Family Guy (1999) creator/star Seth MacFarlane.
- Fourth cousin of Milo Ventimiglia. Milo's mother's paternal grandmother was first cousin to the mother of Dixie Lee. (Dixie was Denise Crosby's grandmother).
- Daughter of Dennis Crosby (whom she is named after) and Marilyn Miller Scott.
- Former daughter-in-law of Blake Edwards
- Son, with Ken Sylk, named August William Sylk (born 17 June 1998).
- Niece of Gary Crosby, Lindsay Crosby, Phillip Crosby, Nathaniel Crosby, Mary Crosby and Harry Crosby.
- Stepdaughter of Pat Sheehan.
- Great-niece of Bob Crosby
- Half-sister of Gregory Crosby, Patrick Anthony Crosby and Dennis Michael Crosby Jr.
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