- Was a multi-millionaire by the time she was 18 years old.
- While filming The Outsiders (1983), co-star Tom Cruise received the script for Risky Business (1983) and asked her to co-star with him in the film as Lana. She stated that her father would "never" let her star as a prostitute and the role went to Rebecca De Mornay.
- 1980: She was hit in the eye with a tennis ball, the impact of which caused permanent pupil dilation.
- Once pursued professional modeling as a teen but was told by Eileen Ford (of the Ford Modeling Agency) that her neck was "too short" to be a model.
- Featured on the cover of Time magazine at age 14. (August 1979)
- In her off time, she likes to travel, ride her horses and go walking. She also enjoys keeping fit and does yoga. She especially loves to spend as much time as possible with her daughter, Eleanor Lambert, whose father is her ex-husband Christopher Lambert of Highlander (1986) fame.
- Her father passed away shortly before Unfaithful (2002), in which she gave an Academy Award-nominated performance, was released. He did see a rough cut of the film three weeks before his death.
- Best friends with Elizabeth Perkins.
- Daughter of acting coach Burt Lane and Playboy centerfold Colleen Farrington (Miss October 1957).
- Collects antique furniture and has a strange fetish - she admitted in Playboy magazine (1995) that she has "a thing for really high thigh-boots. I have a cool collection! I love high heels.".
- Came very close to being cast as Vivian Ward in the blockbuster hit Pretty Woman (1990) (which had a much darker script at the time), but due to scheduling was unable to take the role. Apparently, they had even got as far as costume fittings for her, before the role eventually went to Julia Roberts.
- Has starred with Richard Gere in three movies to date: The Cotton Club (1984), Unfaithful (2002) and Nights in Rodanthe (2008).
- When she was age 13, George Roy Hill wanted her to star opposite Laurence Olivier in his film A Little Romance (1979). At the time, she was working on Broadway for Joseph Papp at the Public Theatre in the original production of "The Runaways". Both Hill and Papp wanted her, and a series of telegrams among Papp, Hill, Olivier and her father transpired, with Hill, Olivier and Diane's father wanting her in the film, and Papp wanting to keep her in the play. She ended up doing the film.
- Separated from her second husband of 8 years Josh Brolin. (February 2013)
- Has co-starred with Matt Dillon in three films: The Outsiders (1983), Rumble Fish (1983) and The Big Town (1987).
- She is a favorite actress of director Francis Ford Coppola and has appeared in four films directed by him: The Outsiders (1983), Rumble Fish (1983), The Cotton Club (1984) and Jack (1996). She also starred in the first of two (as of 2021) non-documentary films directed by Coppola's wife Eleanor Coppola, Paris Can Wait (2016).
- Has said that some of her biggest acting influences have been Jane Fonda, Shirley MacLaine, Jessica Lange and Susan Sarandon.
- 2003: Voted one of People magazine's "Most Beautiful People in the World".
- Two of her movies - Hardball (2001) and The Glass House (2001) - opened in theaters in the United States on the same day (September 14, 2001). They were the top two movies at the box office that weekend.
- One of the "later" members of the Brat Pack, along with John Cusack.
- Works with world hunger charity Heifer International.
- Met first husband Christopher Lambert while filming Priceless Beauty (1988), together. They eventually had a daughter, Eleanor Lambert, and later divorced.
- 2004: Voted one of the "World's Most Desirable Women".
- Turned down the role of Kathryn Murphy in The Accused (1988), which went to Kelly McGillis.
- Admitted in Esquire magazine that she had had affairs with both Timothy Hutton and Christopher Atkins. (February 2000)
- Batman v Superman: Dawn of Justice (2016) and Justice League (2017) were the second and third time Lane has acted with Ben Affleck in a film with a Superman theme. She had previously played Toni Mannix opposite Affleck in Hollywoodland (2006). Toni had a very public affair with Superman actor George Reeves before he allegedly killed himself on June 16, 1959.
- She has English, and some German and Scots-Irish (Northern Irish) ancestry.
- Auditioned for the role of Avery Bishop in Jerry Maguire (1996), which went to Kelly Preston.
- In 2013, this was announced that Lane had been cast as Hillary Clinton in a television miniseries that Fox network was going to produce to air on NBC about the former First Lady. But in August, Fox canceled plans for the production.
- Both Diane and her second ex-husband Josh Brolin have played DC Comics characters. He played the title role in Jonah Hex (2010) while she played Martha Kent, adoptive mother of Clark Kent/Superman in Man of Steel (2013).
- Ex-stepdaughter-in-law of Barbra Streisand.
- She played Toni Mannix in Hollywoodland (2006) while her ex-husband Josh Brolin played Mannix's husband Eddie in Hail, Caesar! (2016).
- Was #79 on VH1's 100 Greatest Kid Stars (2005). Was voted #7 in "VH1's Hottest Over 40".
- Was considered for the role of Ana in the remake of Dawn of the Dead (2004), which eventually went to Sarah Polley.
- As of 2018, has never appeared in a film nominated for the Best Picture Oscar.
- Ex-daughter-in-law of James Brolin.
- Ex-stepmother of Josh Brolin's children, Eden Brolin and Trevor Brolin, from Brolin's first marriage to Alice Adair.
- 2003: Attended the Academy Awards with Josh Brolin.
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