- In addition to her voice-over work, she also provided the voice of automated railroad-defect detectors for the Union Pacific and other railroads. Her voice can be heard on railroad radio channels throughout the nation.
- Majel Barrett and Gene Roddenberry had a Shinto-Buddhist wedding on August 6, 1969. They regarded this as their real wedding, but his divorce was not yet final and they made it legal with a civil ceremony on December 29, 1969. They had one child, Rod Roddenberry. Barrett was the stepmother of actress Dawn Roddenberry and of actress Darleen Anita Roddenberry-Bacha (died on October 29, 1995 in a car accident). Her grandson, Zale Eugene Roddenberry, was born on August 6, 2013, 10:40 p.m. PT, and weighed 6 pounds, 11 ounces.
- Along with Leonard Nimoy, she was one of only two actors to appear in both the first and last episodes of the original Star Trek (1966) series. Is one of only 32 actors or actresses to have starred in both the original Star Trek (1966) (up to and including Star Trek VI: The Undiscovered Country (1991)) and then in one of the spin-offs. She was the only actor to appear in all five live-action "Star Trek" series (Star Trek (1966), Star Trek: The Next Generation (1987), Star Trek: Deep Space Nine (1993), Star Trek: Voyager (1995) and Star Trek: Enterprise (2001)). In addition to this, she supplied various voices on Star Trek: The Animated Series (1973). Along with Joseph Ruskin, Clint Howard, Jack Donner and Vince Deadrick Sr., she was one of only five actors to appear in both Star Trek (1966) and Star Trek: Enterprise (2001). Shortly before her death, she completed voice-over work as the voice of the Enterprise's main computer for J.J. Abrams' Star Trek (2009) remake.
- Best known for her roles as Nurse Christine Chapel on the original Star Trek (1966) series and as Lwaxana Troi on Star Trek: The Next Generation (1987) and Star Trek: Deep Space Nine (1993). She played the mother of two Enterprise crew members: Lwaxana Troi and on Star Trek: The Animated Series (1973), she played Amanda Grayson as Jane Wyatt was unavailable.
- Attended and graduated from Shaker Heights High School in Shaker Heights, Ohio (Class of 1950). Attended and graduated from the University of Miami in Coral Gables, Florida.
- Majel Barrett Roddenberry died on December 18, 2008, aged 76, from leukemia.
- Being aged 76 at the time of her death, she is the shortest-lived of the nine regular Star Trek (1966) series cast members.
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