- Learning to fly-fish; his teacher is Liam Neeson.
- Was originally offered Tom Cruise's role in Top Gun (1986). Turned down the part because he disagreed with the film's cold-war politics.
- Is a horticulturist and a carpenter.
- Is a neighbor of Liam Neeson.
- Founder of Bicycle For A Day (BFAD), a global initiative bringing together people who choose to ride a bicycle rather than use gas-powered motor vehicles, immediately reducing their carbon footprint.
- Streamers (1983) co-star David Alan Grier was the godfather of his two children.
- Good friends with Eric Stoltz.
- In a radio interview with Jonathan Ross in late February 2006, he said he was only baptized a Mormon, but the family wasn't very orthodox or 'tight-knit', and only practiced seriously during his very early years.
- Has a son Boman Modine (b. 8 November 1985) and a daughter Ruby Modine (b. 31 July 1990).
- Loves to paint.
- Martin Short's Hollywood-obsessed character, Jiminy Glick, has sons named Matthew and Modine.
- His paternal great-grandfather, Andrew Daniel Andreassan Modine, was Swedish. His other ancestry is English, with some Scottish, German, and Dutch.
- Attended Brigham Young University.
- Studied acting with Stella Adler.
- Starred in three movies about the Vietnam War: Streamers (1983), Birdy (1984) and Full Metal Jacket (1987).
- Was friends with Edward Asner.
- The Montreal-based band "Pony up!" wrote a song about him called "Matthew Modine" because one of the girls used to have a huge crush on him. You can find the song on the band first LP called "Pony up!".
- He is the only actor to have worked with Stanley Kubrick and Christopher Nolan.
- Was member of the dramatic jury at the Sundance Film Festival in 1994.
- Alumnus of Stella Adler Studio of Acting.
- Nephew of former Broadway star Nola Modine Fairbanks.
- Grandfather of Avery Modine, son of Boman Modine.
- Brother of Mark Modine.
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