- Became a Canadian citizen in 2008, and now holds dual US/Canadian citizenship.
- She turned down the role played by Courteney Cox in Ace Ventura: Pet Detective (1994), but later co-starred with Jim Carrey in Dumb and Dumber (1994).
- Her mother, Michael Ann, taught art history at the University of Rochester and chaired the department.
- Her father, Grant Holly, taught English Literature at Hobart and William Smith Colleges in Geneva, New York.
- Her maid of honor at her March 2001 wedding to Francis Greco was actress Amanda Peet
- Played "Mary Ann", best friend of abused wife, "Wanda" (played by Jane Krakowski) in The The Chicks' 2000 video, "Goodbye Earl", with Dennis Franz as "Earl".
- Ex-daughter-in-law of Anthony Quinn and Jolanda Addolori.
- Graduated from Geneva High School in Geneva, New York (Class of 1981) where she was a cheerleader. Attended Sarah Lawrence College (graduated 1985 with a degree in English Literature).
- In 2014, she was reunited with her ex-Picket Fences (1992) series' star, Tom Skerritt, to star in the movie Field of Lost Shoes (2015).
- Has been tapped to join the CBS production of NCIS (2003) and will debut in the first episode of the season as "Jenny Shepard", the new boss of the Naval criminal investigative unit where Gibbs works. (August 2005)
- Younger brother, Nick Holly, was a literary agent in Hollywood at Don Buchwald and Assoc. He is now a writing partner with Fred Goss.
- Ex-husband Francis Greco is an investment banker. The couple has three adopted sons: Alexander Joseph Greco (b. 2001), George Greco (b. 2003) and Henry Greco (b. 2004). She has called her sons "the three kings". Alexander Greco was named for Holly's own 14-year-old brother, Alexander Innes Holly (July 11, 1977 - April 10, 1992) who died in a fire.
- Was married to Jim Carrey for a year, during which time she was stepmother to Jane Carrey.
- Shared a dressing room for three years with Robin Christopher and Rosa Nevin when they worked together at All My Children (1970).
- Ex-sister-in-law of Faith Salie, Alex A. Quinn, Melissa Quinn, Francesco Quinn, Lorenzo Quinn and Valentina Quinn.
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