- His novels were so carefully plotted that he never wrote a second draft.
- At the Bouchercon 2000, he was nominated Best Mystery Writer of the Century and the Nero Wolfe corpus was nominated Best Mystery Series of the Century.
- In 1958, 14th President of the Mystery Writers of America. In 1959, he received the MWA's Grand Master Award.
- The creator of famous sleuth Nero Wolfe began his career as a writer of psychological novels. He was also a businessman. The Wall Street crash of 1929 forced him to recoup his losses by writing the financially more lucrative detective fiction.
- A longtime friend of P.G. Wodehouse (they both died in 1975). Wodehouse contributed the foreword to John McAleer's Edgar-winning "Rex Stout: A Biography".
- During WWII he was active in the Fight for Freedom organization and wrote anti-Nazi propaganda. He also coordinated the volunteer services of American writers to help the war effort.
- While on the US Navy (1906-1908) he served as a yeoman on President Theodore Roosevelt's yacht.
- President of the Authors Guild.
- Died at his home at Danbury, Connecticut.
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