- Along with Troy Donahue, he was the inspiration for the character Troy McClure on The Simpsons (1989).
- He was awarded a Star on the Hollywood Walk of Fame for Television at 7065 Hollywood Boulevard in Hollywood, California on November 16, 1994.
- Played the Errol Flynn role in a remake of Against All Flags (1952) titled The King's Pirate (1967). Coincidentally, both men died prematurely: Flynn at age 50 and McClure at age 59.
- He reportedly enjoyed the character Troy McClure on The Simpsons (1989), for whom he served as the main inspiration alongside Troy Donahue, and his children would affectionately address him by the character's name behind his back.
- Following his death, he was interred at Woodland Memorial Cemetery in Santa Monica, California. He passed away on February 5, 1995, three months away from what would have been his 60th birthday on May 11.
- Best remembered by the public for his role as "Trampas" on The Virginian (1962).
- Ex-father-in-law of Jonathan Cain.
- Not related to fellow actor Marc McClure, despite a popular misconception.
- Doug McClure and James Drury both appeared on all 249 episodes of The Virginian (1962). They were the only two actors who even came close to being in every episode.
- Doug had a role on Maverick near the beginning of his career- and again near the end.
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