- He is the youngest guest to be interviewed by Johnny Carson on "The Tonight Show". Hughes was 4 years old when he was interviewed on February 20, 1991, two days before his fifth birthday.
- In 1998, he kept 30,000 bees in his backyard beehive.
- Has played 2 characters on the Autism spectrum. Simon Lynch in Mercury Rising (1998), and Timmy Grayson in the Baywatch episode, Dolphin Quest (1998).
- One of four children of John Hughes (a special effects technician) and his wife, Mary Hughes, Miko and his siblings (Molly, Mikhael & Mitchell) are of American (Chickasaw) descent on their mother's side. Miko's name means Chief in Chickasaw.
- Is of Native American descent (Chickasaw) from his mother's side.
- Miko appeared in a 1995 McDonald's commercial where he and a girl (his sister) had to clean up their room. Ronald McDonald successfully aids them with his magic.
- His father, John Hughes, was a special effects technician. In New Nightmare (1994), the father of his character Dylan also worked in special effects.
- His name is pronounced Me-ko.
- Living in Apple Valley, CA. He is acting during the day and is a DJ at night. (October 2006)
- Has a cat named Spaz.
- In the 1990s, his mother, Mary Hughes wrote the screenplay for a film based on her Native American grandmother, Zuma Odell Chaney, titled "Five At Dawn". Kent Bateman was attached to direct the film. Miko was to appear at the beginning and end of the movie, listening to his great-grandfather tell him about 1900 in the year 2000. However, the film was never made.
- The face he makes after saying "When we get to the museum, we gotta see those dead guys wrapped up in toilet paper" as Aaron Bailey in a scene from season 6, episode 18 of Full House (1987), "Please Don't Touch the Dinosaurs", became a popular internet meme in Brazil in 2016 named "Por que você não amadurece?" (Why don't you mature?), often used in response when someone whines about something. A page for the meme was created on Facebook in Portuguese and gained over 300k likes in less than 24 hours. Hughes thanked the Brazilian fans for the meme in his social media accounts.
- Hughes played the truck driver who accidentally runs over Gage Charnas in the music video for the song "Funeral Derangements" by American metalcore band Ice Nine Kills.
- Has a sister, Molly and 2 brothers, Mikhael & Mitchell.
- Is friends with actor Joey Zimmerman.
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