1971's "Brain of Blood" was strictly work for hire as Al Adamson's addition to Hemisphere's trio of 'Blood Island' entries, minus the wooden presence of John Ashley (his "Beast of the Yellow Night" went out through Roger Corman's New World Pictures, so Hemisphere needed a replacement quickly), with Adamson's usual cast of characters for location shooting over 8 days in California rather than the humid Philippines (sadly, no scantily clad jungle beauties). Two ailing actors emerged for one last film role, TV veteran Reed Hadley as dying Kalid ruler Abdul Amir, and Incredible Shrinking Man Grant Williams, whose heroic Dr. Bob Nigserian is given the task of maintaining complete secrecy in keeping Amir's brain alive long enough to transplant from its current cancerous body to a younger, stronger one. Reliable Kent Taylor offers continuity from "Brides of Blood" as mad scientist Lloyd Trenton, the surgeon assisted by dwarf Dorro (Angelo Rossitto) in the delicate operation that will enable him to realize his goal of taking over a Middle Eastern nation. Problems arise when the doctor's mentally deficient henchman Gor (7'4 John Bloom) supplies damaged goods, requiring Gor's noggin to house the brain of Amir, coupled with a special tracking device in his skull that enables Trenton to bend this subject to his will. Meantime, Bob's car is forced off the road by a treacherous Trenton confederate (Richard Smedley), and even Amir's trusted fiancee Tracy (Regina Carrol) turns out to be a heartless harlot, another profiteer itching to earn the ultimate payoff. Apart from Amir's unhappy new countenance, scarred by battery acid, the only one standing in Trenton's way is Bob, the lone survivor of the wreck, but even he cannot prevent the inevitable from happening, a whole host of corpses left behind. It certainly delivers on its promise of blood and brains but very little else, a plot that just dangles like a loose tooth waiting to drop despite the high death count, the picture slowing to a crawl over the entire second half, essentially a simple minded chase picture with everybody on foot. Williams ably carries things along in a part tailor made for him, Kent Taylor repeating his mad doctor from "Blood of Ghastly Horror," Angelo Rossitto and Zandor Vorkov reunited from "Dracula vs. Frankenstein." Vorkov, better known as stockbroker Roger Engel, actually improves on his pasty faced Dracula as Amir disciple Mohammed, lasting a half hour before crashing in a blaze of glory, never again acting before the camera.