No Smoking is a short that serves as the pilot to the Cow & Chicken series, and is somewhat considered taboo nowadays due to it being about smoking.
In this, Cow has to suit up to become Supercow to save Chicken, who is captured by the Devil (the character who would eventually be redone into the Red Guy, which allowed him to do more jobs and become the series main antagonist), when the red guy (who is also butt naked) takes the older brother to the underworld after finding out he smokes.
This short is a basic introduction to the absurdity that made Cow & Chicken a beloved classic. From Cow becoming Supercow, a superheroine that hides her identity by only speaking Spanish, to the gross humor that the show would become famous to kids (and infamous by some parents and watchdog groups), Banned by the network due to its subject matter of smoking and depicting Hell and the Devil (which could be the reason for the Devil being redone to be The Red Guy we know and love), No Smoking is a neat short introducing us to what would become Cartoon Network's Ren and Stimpy.