I understand how so many people find Uncle Grandpa hard to watch or find it too trippy and hallucinogenic to stomach. But if you know the history of animation and enjoy surrealism, Uncle Grandpa is a BLAST!
Golden Age animator Tex Avery once said, "If you can do it in real life, it isn't animation." Uncle Grandpa embraces that philosophy and runs with it. Every animation gimmick you've ever seen appears at one time or another. Stuff out of the frame (including body parts) cease to exist, perspective gags galore, selective gravity, photo cut-outs, sight gags, visual puns, internet memes, breaking the 4th wall... Don't even try to keep a list, there are too many.
My only complaint about Uncle Grandpa is that sometimes it's a little too NORMAL. I can get normalcy any day without turning on the TV.