So many successful sitcoms depend on likable buffoons as major characters that one's first impression of "Josh" is that he is just another self-deprecating target for stale jokes about his shortcomings. In this case, the eponymous actor/creator moves well beyond the predictable into a realm of hyper-originality rarely seen in a TV series. Nothing here is predictable. Each scene, each comedic line, each nuance bordering on serious personality issues comes across as going against the grain of laugh track one-liners.
I viewed the first two seasons in quick sequence to determine some thread justifying the title "Please Like Me." There is so much more than that at work here I came to the conclusion that "Josh" intends his imperative to apply to the entire narrative rather than just himself. None of the main characters is one-dimensional. Each one stands alone in all sorts of revealing personal aspects. Attraction of one to another is quickly reversed or brought down to earth before sentimental attachments rear up to spoil the moment.
Of course "Josh" is unerringly annoying. Surrounded by bipolar types and deliberately handsome but flawed lovers he has little choice.
This is a fascinating series, which I hope to be able to follow as it progresses.