Of course, you gotta be a masochist to enjoy some people's genius - you know that if you bear with them they will take you to new levels of perception.
With Lars von Trier, the voyage is often hilarious. Epidemic is funny. Funny, in a Gummo kind of way: the characters are real, reality is eerie, and we laugh to break the tension; funny in a the characters say amusing things kind of way (preacher: "this bible is in goddamned Latin"); and funny in an Andy Kaufman screwing with the audience (yes, you) kind of way.
Make no mistake: you will suffer. If you are afraid, stay away from horror movies, ya pansy!
This movie also features some great aesthetic distance! It's bold!