Muriel Buck Humphrey est née le 20 février 1912 dans le Dakota du Sud, États-Unis. Elle était mariée à Max Brown et Hubert H. Humphrey. Elle est morte le 20 septembre 1998 dans le Minnesota, États-Unis.
At the time of her death, in addition to son Hubert H. Humphrey III; she had a daughter, Nancy Humphrey Solomonson; two additional sons, Robert Humphrey and Douglas Humphrey; 12 grandchildren; and 3 great grandchildren. From her second marriage, she was also the step-mother of two adult children, and grandmother to 5 more grandchildren.